Experimental Epilepsy Group

Department of Clinical and Experimental Epilepsy


Institute of Neurology

 

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Selected PDFs:

 

Asztely F, Erdemli G & Kullmann DM (1997) Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake. Neuron 18, 281-293. PDF file

Kullmann DM & Asztely F (1998) Extrasynaptic glutamate spillover in the hippocampus: evidence and implications. Trends in Neurosci. 21, 8-14. PDF file

Min M-Y, Asztely F, Kokaia M & Kullmann DM (1998) Long-term potentiation and dual-component quantal signalling in the dentate gyrus. Proc. Natl. Acad. Sci. USA 95, 4702-4707. PDF file

Rusakov DA & Kullmann DM (1998) Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake and receptor activation. J. Neurosci. 18, 3158-3170. PDF file

Rusakov DA & Kullmann DM (1998) Geometric and viscous components of the tortuosity of the extracellular space in the brain. Proc. Natl. Acad. Sci. USA 95, 8975-8980. PDF file

Min M-Y, Rusakov DA & Kullmann DM (1998) Activation of AMPA, kainate and metabotropic receptors at hippocampal mossy fiber synapses: role of glutamate diffusion. Neuron 21, 561-570. PDF file

Kullmann DM, Min M-Y, Asztely F & Rusakov DA (1999) Extracellular glutamate diffusion determines the occupancy of glutamate receptors at CA1 synapses in the hippocampus. Phil. Trans. R. Soc. Lond. B 354, 395-402. PDF file

Rusakov DA, Kullmann DM & Stewart MG (1999) Hippocampal synapses: do they talk to their neighbours? Trends in Neurosci. 22, 382-388. PDF file

Min M-Y, Melyan Z & Kullmann DM (1999) Synaptically released glutamate reduces g-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors. Proc. Natl. Acad. Sci. USA 96, 9932-9937. PDF file

Zuberi SM, Eunson LH, Spauschus A, De Silva R, Tolmie J, Wood NW, McWilliam RC, Stephenson JP, Kullmann DM & Hanna MG (1999) A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with epilepsy. Brain 122, 817-825. PDF file

Eunson LH, Rea R, Zuberi SM, Youroukos S, Panayiotopoulos CP, Liguori R, Avoni P, McWilliam RC, Stephenson JP, Hanna MG, Kullmann DM, & Spauschus A (2000) Clinical, genetic and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability. Ann. Neurol. 48, 647-656. PDF file

Semyanov A & Kullmann DM (2000) Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors. Neuron 25, 663–672. PDF file

This schematic shows how we demonstrated that glutamate released from excitatory synapses depresses GABA release from neighbouring inhibitory synaptic terminals. This heterosynaptic regulation of inhibition could play a role in seizure initiation. See Semyanov & Kullmann (2000).

 Walker MC, Ruiz A & Kullmann DM (2001) Monosynaptic GABAergic Signaling from Dentate to CA3 with a Pharmacological and Physiological Profile Typical of Mossy Fiber Synapses. Neuron 29, 703–715. PDF file

Semyanov A & Kullmann DM (2001) Kainate receptor-dependent axonal depolarization and action potential initiation in interneurons. Nature Neurosci. 4, 718 - 723. PDF file

Kullmann DM (2001) Presynaptic kainate receptors in the hippocampus: slowly emerging from obscurity. Neuron 32, 561 - 564. PDF file

Jouvenceau A, Eunson LH, Spauschus A, Ramesh V, Zuberi SM, Kullmann DM & Hanna MG (2001) Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel. Lancet 358, 801-807.PDF file

Rea R, Spauschus A, Eunson LH, Hanna MG & Kullmann DM (2002) Variable K+ channel subunit dysfunction in inherited mutations of KCNA1. J Physiol 538: 5-23. PDF file

Kullmann DM (2002) The neuronal channelopathies. Brain 125:1177-95 PDF File

Kullmann DM & Hanna MG (2002) Inherited neurological diseases caused by ion channel mutations. Lancet Neurology  1: 157-166 PDF File

Rea R, Tijssen MA, Herd C, Frants RR & Kullmann DM (2002) Functional characterization of compound heterozygosity for GlyRalpha1 mutations in the startle disease hyperekplexia. Eur J Neurosci. 16:186-96. PDF File

Rusakov DA, Lehre KP (2002) Perisynaptic asymmetry of glia: new insights into glutamate signalling. Trends Neurosci 25:492-4. PDF file

Chandler K, Princivalle AP, Fabian-Fine R, Bowery NG, Kullmann DM, Walker MC (2003). Plasticity of GABAB receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus. J Neurosci 23:11382–11391 PDF File

Semyanov A, Walker MC & Kullmann DM (2003) GABA uptake regulates cortical excitability via cell type-specific tonic inhibition.
Nat Neurosci. 6:484-90.  PDF file

Ruiz A, Fabian-Fine R, Scott R, Walker MC, Rusakov DA & Kullmann DM (2003) GABAA receptors at hippocampal mossy fibers. Neuron. 39: 961-73.  PDF file

Kullmann DM (2003) Silent synapses: what are they telling us about LTP? Phil Trans Roy SocLond. B 358, 727–733. PDF File

Rusakov DA and Fine A (2003). Extracellular Ca2+ depletion contributes to fast activity-dependent modulation of synaptic transmission in
the brain. Neuron 37:287-97. PDF File

Imbrici P, Jaffe SL, Eunson LH, Davies NP, Herd C, Robertson R, Kullmann DM, Hanna MG (2004) Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia. Brain.  127:2682-92. PDF File

Ruiz A, Walker MC, Fabian-Fine R, Kullmann DM (2004) Endogenous zinc inhibits GABA(A) receptors in a hippocampal pathway. J Neurophysiol. 91:1091-6. PDF file

Rusakov DA, Wuerz A, Kullmann DM (2004) Heterogeneity and specificity of presynaptic Ca2+ current modulation by mGluRs at individual hippocampal synapses. Cerebral Cortex DOI: 10.1093/cercor/bhh035 PDF File

Semyanov A, Walker MC, Kullmann DM, Silver RA (2004) Tonically active GABAA receptors: modulating gain and maintaining the tone. Trends in Neurosci. 27(5):262-9. PDF File

Scimemi A, Fine A, Kullmann DM, Rusakov DA (2004) NR2B-containing receptors mediate cross talk among hippocampal synapses. J Neurosci. 2004 24:4767-77. PDF File

Scimemi A, Semyanov A, Sperk G, Kullmann DM, Walker MC (2005). Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus. J Neurosci. 25:10016-24. PDF File

Lamsa K, Heeroma J, Kullmann DM (2005) Hebbian LTP in feed-forward inhibitory interneurons and the temporal fidelity of input discrimination. Nat Neurosci. 8:916-24. PDF File

Volynski K, Rusakov DA, Kullmann DM (2006) Presynaptic fluctuations and release-independent depression. Nat Neurosci. 9:1091-3. PDF File

Lamsa K, Heeroma J, Somogyi P, Rusakov DA, Kullmann DM (2007) Anti-Hebbian LTP in the hippocampal feedback inhibitory circuit. Science. 315:1262-6. Abstract Full Text

Wanaverbecq N, Semyanov A, Pavlov I, Walker MC, Kullmann DM (2007) Cholinergic axons modulate GABAergic signaling among hippocampal interneurons via postsynaptic alpha 7 nicotinic receptors.
J Neurosci. 27:5683-93 PDF File

 

 

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